Multiple myeloma is a type of blood cancer. It starts in your bone marrow, the spongy tissue inside bones. This is where your body makes blood cells, including a certain type called plasma cells. These cells can grow out of control and crowd out the normal, healthy ones in your bone marrow.
Multiple myeloma can cause pain in affected bones – usually the back, ribs or hips. The pain is frequently a persistent dull ache, which may be made worse by movement.
Myeloma occurs most commonly in people over 60. The average age at diagnosis is 70. Only 2% of cases occur in people under 40.
Exposure to toxic chemicals, atomic radiation, anything that interferes with the immune system, or infection with cancer-causing viruses have all been implicated as causes or triggers of myeloma. Toxic chemicals that have been identified include: benzene. dioxins (such as those found in Agent Orange)
In some patients, large amounts of myeloma protein can cause the blood to “thicken.” This thickening is called hyperviscosity. It can slow blood flow to the brain and cause: Confusion. Dizziness.
Nerve damage: Myeloma proteins can be toxic to your nerves. This can lead to a condition called peripheral neuropathy that causes a pins-and-needles feeling, often in your legs and feet.
Stress can be a very destructive force when it comes to myeloma. Stress really disrupts the immune system and myeloma is a cancer of the immune system. In addition, the stress hormone noradrenaline (the "flight" hormone, versus adrenaline, the "fight" hormone) can actually trigger cancer cell growth directly.
Conclusions: In this study, we observed no significant association between coffee or green tea consumption and the risk of malignant lymphoma or multiple myeloma.
Good sources of fiber include:
May 27, 2021
While multiple myeloma doesn't yet have a cure and can be fatal, patients' life expectancies vary widely, according to Jens Hillengass, MD, Chief of Myeloma at Roswell Park Comprehensive Cancer Center. “I have seen patients live from several weeks to more than 20 years after being diagnosed,” Dr. Hillengass says.
Today, a multiple myeloma diagnosis is no longer a death sentence because our community's efforts have helped bring 11 new drugs through FDA-approval.
How quickly multiple myeloma progresses can vary between people. An older 2007 study of 276 people found that there was a 10% risk of progression in people with early multiple myeloma per year for the first 5 years of illness.
Multiple myeloma is an uncommon cancer of the blood. The median length of survival after diagnosis with multiple myeloma is 62 months for Stage I, 44 months for Stage II, and 29 months for Stage III. Life expectancy depends on many factors, including the person's age, health, kidney function, and more.
Multiple myeloma is a type of blood cancer for which there is no cure. In 2020, of all patients newly diagnosed with a blood cancer, 18% are expected to be diagnosed with this type of blood cancer. Depending on the stage, the average survival rate is five to seven years.
If left untreated, excess amounts of myeloma protein can cause kidney damage or even renal failure. A kidney biopsy might be performed to determine the exact cause of the kidney damage.
Selinexor (Xpovio) is a new type of multiple myeloma drug called a selective inhibitor of nuclear export (SINE). The FDA approved it for treatment of relapsed or refractory disease in July 2019. It's combined with dexamethasone and is used to treat people who've tried at least four previous therapies.
Weight-bearing exercises (in which your bones support your own weight) like walking, climbing stairs, or dancing, can help to strengthen bones. Be sure to contact your physician if weight-bearing activity leads you to experience bone pain, or a change in your pain symptoms.
Excellence in bone marrow transplant care by Mayo Clinic's bone marrow transplant team, which is recognized internationally for expertise in comprehensive specialty treatment for people with blood and bone marrow diseases, including multiple myeloma.
Radiation therapy, which uses high-energy particles or rays to damage cancer cells and prevent them from growing, is proven to effectively treat multiple myeloma in specific situations and/or reduce complications from bone disease. Radiation therapy may also be called radiotherapy, X-ray therapy, or irradiation.